University of Pennsylvania · BiologyAutoimmunity and X-Chromosome Research Lab
Montserrat C Anguera · Philadelphia, Pennsylvania
Research Focus
Dr. Montserrat C Anguera's lab at the University of Pennsylvania focuses on understanding why females are more prone to developing systemic lupus erythematosus, an autoimmune disease. The lab studies how the X-chromosome, which carries many immunity-related genes, behaves differently in female B cells, particularly under chronic inflammation conditions. By examining gene regulation processes and epigenetic changes, they aim to reveal new insights into disease mechanisms and potential therapeutic targets for lupus.
autoimmunitysystemic lupus erythematosusX-chromosome inactivationB cellsepigenetics
Research Aims
3AIM 01Investigate how chronic inflammation from type I IFN affects X-linked gene expression in B cells.
AIM 02Determine if aberrant biallelic transcription and epigenetic modifications occur in SLE patients' B cells.
AIM 03Examine the role of nuclear matrix proteins in maintaining XCI in B cells.
Skills the Lab Values
RNA sequencingmouse modelsDNA methylation analysisflow cytometryPCR
Output against the department
Publications49bottom 11% of dept.913th of 1,033
this lab
most publishedleast published
Citations1.8kbottom 12% of dept.914th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.