University of Toledo · BiologyTriple-Negative Breast Cancer Therapeutics Lab
Jian-Ting Zhang · Toledo, Ohio
Research Focus
Dr. Jian-Ting Zhang's lab focuses on developing new treatment strategies for triple-negative breast cancer (TNBC), a type of breast cancer that often resists existing therapies. The lab is investigating how fatty acid synthase (FASN) contributes to resistance against certain cancer drugs and exploring the potential of combining proton pump inhibitors with these drugs to enhance their effectiveness. By targeting FASN, the lab aims to improve survival rates and reduce the side effects of current treatments for TNBC patients.
triple-negative breast cancerFASNPARP inhibitorsproton pump inhibitorssynthetic lethality
Research Aims
3AIM 01Identify how FASN contributes to PARP inhibitor resistance.
AIM 02Determine the effects of proton pump inhibitors on FASN activity.
AIM 03Evaluate the combination of proton pump inhibitors with PARP inhibitors in cancer treatment.
Skills the Lab Values
cell culturemolecular cloningWestern blottingRNA isolationanimal modelsdrug combination testingbiochemical assaysreal-time PCR
Output against the department
Publications265top 22% of dept.231st of 1,033
this lab
most publishedleast published
Citations7.7ktop 48% of dept.495th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.