New York University · NeuroscienceMemory and Protein Translation Lab
Eric Klann · New York, New York
Research Focus
Dr. Eric Klann's lab at New York University focuses on understanding how protein synthesis affects memory and language in brain disorders. By studying specific brain regions in mice, they aim to uncover the processes behind memory storage, retrieval, and loss. They are also investigating how abnormalities in protein translation contribute to diseases like Alzheimer's and fragile X syndrome, with hopes of finding new treatment targets.
memoryprotein synthesistranslational controlAlzheimer's diseasefragile X syndromeautism spectrum disordersynaptic plasticityneurodegenerative disorders
Research Aims
5AIM 01Investigate the role of protein synthesis in memory processes such as consolidation and extinction.
AIM 02Identify cell types in the amygdala and hippocampus critical for memory related to fear and context.
AIM 03Explore how dysregulated translation affects behavior in neurodegenerative diseases.
AIM 04Utilize advanced techniques to examine mRNA and protein synthesis in affected neurons.
AIM 05Develop therapeutic insights for brain disorders associated with translation dysfunction.
Skills the Lab Values
electrophysiologyimmunocytochemistrymouse modelsribosomal profilingde novo proteomicsgene editingtranslatomic analysiscomplex behavioral paradigms
Output against the department
Publications258top 28% of dept.185th of 671
this lab
most publishedleast published
Citations24ktop 17% of dept.112th of 671
this lab
most citedleast cited
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