University of California-San Francisco · NeuroscienceOstrem Lab
Bridget Lamonica Ostrem · San Francisco, California
Research Focus
Dr. Bridget Ostrem's lab at UCSF focuses on developing new treatments for premature infants suffering from white matter injury, a common and serious type of brain damage. The lab uses innovative screening methods to find compounds that can promote the repair of damaged brain cells and conduct clinical trials to test the safety and efficacy of these treatments. This research aims to provide effective therapies for conditions like cerebral palsy and learning disabilities that can arise from these injuries.
premature brain injuryremyelinationwhite matter injuryneonatal neurologyclinical trialsdrug discoveryhigh-throughput screeningoligodendrocyte differentiationtherapeutics
Research Aims
5AIM 01Identify compounds that promote brain cell repair in premature infants.
AIM 02Develop and validate therapeutic pipelines for white matter injury treatments.
AIM 03Conduct Phase I clinical trials to assess safety of promising remyelinating compounds.
AIM 04Establish a systematic approach for drug testing in neonatal brain injuries.
AIM 05Explore the long-term neurodevelopmental outcomes of treated infants.
Skills the Lab Values
high-throughput screeningin vitro testingclinical trial designanimal modelsneuroimaging techniquespharmacokineticsdata analysismolecular biology techniquesbasic histology
Output against the department
Publications17bottom 3% of dept.654th of 671
this lab
most publishedleast published
Citations282bottom 2% of dept.657th of 671
this lab
most citedleast cited
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