University of California-Los Angeles · PharmacologymRNA Cancer Immunotherapy Lab
Caius Gabriel Radu · Los Angeles, California
Research Focus
Dr. Caius Gabriel Radu's lab is focused on creating innovative mRNA vaccines aimed at improving cancer treatment, specifically for pancreatic cancer. The research explores how these vaccines can enhance therapies that involve transferring immune cells to fight tumors. By studying these vaccines in complex mouse models that mimic human immune systems, the lab aims to address challenges in current cancer therapies and develop effective treatments for patients with difficult-to-treat cancers.
mRNA vaccinespancreatic cancerT-cell therapycancer immunotherapyKRAS inhibitorstumor microenvironmenthumanized mouse modelsimmunogenicityvaccine design
Research Aims
5AIM 01Engineer new mRNA vaccines targeting pancreatic cancer antigens.
AIM 02Evaluate vaccine efficacy in humanized immune system mouse models.
AIM 03Understand the effects of mRNA vaccines on immune cell activation.
AIM 04Investigate the role of KRAS inhibitors in enhancing vaccine efficacy.
AIM 05Develop combination therapies that improve cancer treatment outcomes.
Skills the Lab Values
PCRcell culturemouse modelsflow cytometryWestern blotRNA sequencingbiostatisticsanimal handlingbioinformaticsvaccine formulation
Output against the department
Publications373top 17% of dept.80th of 462
this lab
most publishedleast published
Citations9.7ktop 39% of dept.181st of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.