University of Illinois Urbana-Champaign · BiochemistryOxygen Resilience Lab
James A. Imlay · Champaign, Illinois
Research Focus
Dr. James A. Imlay's lab studies how bacteria cope with the challenges posed by oxygen and reactive oxygen species. Bacteria have evolved various defenses to counteract the damaging effects of oxidative stress that can harm their enzymes and DNA. By investigating how different bacteria produce and manage reactive oxygen species, the lab aims to enhance our understanding of bacterial survival and adaptation in oxygen-rich environments, potentially leading to better antibiotic development.
oxidative stressreactive oxygen speciesanaerobic bacteriaDNA repairantibioticsmicrobial physiologyenzyme protectionoxidation-reductionbacterial survival
Research Aims
5AIM 01Identify enzymes in bacteria that contribute to reactive oxygen species production.
AIM 02Understand the variability in oxidative stress sensitivity among different bacterial species.
AIM 03Explore the mechanisms through which bacteria repair oxidative damage to their DNA.
AIM 04Develop engineered bacteria with enhanced tolerance to oxidative stress.
AIM 05Investigate the effects of redox-active antibiotics on bacterial DNA.
Skills the Lab Values
spectrophotometrybacterial culturemolecular cloningDNA sequencingbiochemical assaysprotein purificationoxidative stress analysisgenetic engineeringenzyme kinetics
Output against the department
Publications148bottom 41% of dept.237th of 402
this lab
most publishedleast published
Citations28ktop 13% of dept.52nd of 402
this lab
most citedleast cited
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