UTMThe University of Texas MD Anderson Cancer Center · Microbiology & Immunology
Naora Metastasis Lab
Honami Naora · Houston, Texas
Research Focus
Dr. Honami Naora's lab investigates how age impacts the spread of ovarian cancer to the omentum, a fatty tissue that can be a site for cancer metastasis. By understanding how certain immune cells, like innate-like B cells, contribute to this process, the lab aims to develop strategies to reduce the risk of cancer spreading in older women. The research combines animal studies, human samples, and innovative techniques to uncover mechanisms driving these changes in metastasis.
ovarian cancermetastasisaginginnate-like B cellsomentumcancer immunologyimmunotherapycell homingwomen's healthmouse models
Research Aims
4AIM 01Identify how aging increases the metastatic competence of the omentum.
AIM 02Determine whether homing of innate-like B cells to the omentum is increased in aged females.
AIM 03Delineate mechanisms that can suppress homing of innate-like B cells to the omentum.
AIM 04Develop strategies to decrease metastatic competence in older females.
Skills the Lab Values
cell cultureanimal modelsflow cytometrygene editing (CRISPR)single cell analysisimmune cell profilingpharmacological testingadoptive cell transfermolecular biology techniquesclinical specimen analysis
Output against the department
Publications155top 42% of dept.205th of 486
this lab
most publishedleast published
Citations4.9kbottom 37% of dept.307th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.