Baylor College of Medicine · Microbiology & ImmunologyHyser Calcium Lab
Joseph M. Hyser · Houston, Texas
Research Focus
Dr. Joseph M. Hyser's lab at Baylor College of Medicine studies how viruses, particularly rotavirus, manipulate calcium signaling pathways in host cells to enhance their replication and spread. The lab focuses on understanding the mechanisms behind rotavirus-induced calcium signals, exploring both the viral strategies that exploit these pathways and the host's physiological responses. This research could pave the way for new antiviral therapies by identifying key cellular interactions involved in virus-host dynamics.
RotavirusCalcium signalingViral replicationHost-pathogen interactionGastroenteritisIntercellular signalingEpithelial responsesAntiviral therapyCalcium dysregulation
Research Aims
3AIM 01Characterize the RV-induced ADP release pathway from infected cells.
AIM 02Investigate P2Y1-mediated responses to rotavirus infection in the gut.
AIM 03Determine how rotavirus exploits calcium signaling to enhance replication and spread.
Skills the Lab Values
Calcium imagingCell cultureMolecular cloningWestern blotFlow cytometryRNA extractionQuantitative PCRImmunofluorescenceAnimal modelsBiochemical assays
Output against the department
Publications93bottom 32% of dept.330th of 486
this lab
most publishedleast published
Citations3.3kbottom 24% of dept.369th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.