Brown University · Microbiology & ImmunologyLee Lab
Sanghyun Lee · Providence, Rhode Island
Research Focus
Dr. Sanghyun Lee's lab at Brown University focuses on understanding how viruses evade the immune responses of intestinal epithelial cells during infections. The research involves studying specific viral proteins that interact with cellular receptors to suppress immune signaling pathways. The lab aims to uncover the mechanisms behind these interactions to better understand enteric viral infections and potential therapeutic targets.
viral immune evasionnorovirusintestinal immunityRIG-I signalingvirokinecellular receptorsmurine modelsinterferon responsesenteric infections
Research Aims
4AIM 01Investigate how norovirus evades immune detection in intestinal cells.
AIM 02Identify specific receptors involved in viral immune evasion.
AIM 03Explore the role of surrounding cells in enhancing immune responses.
AIM 04Assess the impact of viral proteins on interferon signaling pathways.
Skills the Lab Values
cell culturemouse modelsRNA extractionimmunofluorescence microscopyflow cytometryCRISPRviral assay techniquesprotein purificationquantitative PCR
Output against the department
Publications735top 3% of dept.13th of 486
this lab
most publishedleast published
Citations11ktop 34% of dept.164th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.