University of Connecticut · ChemistryEpitranscriptomic Innovations Lab
Daniele Fabris · Storrs, Connecticut
Research Focus
Dr. Daniele Fabris and his lab at the University of Connecticut focus on developing new techniques for analyzing large, modified RNA molecules using mass spectrometry. They aim to overcome current challenges in identifying RNA modifications, which are crucial for understanding emerging biotherapeutics and the regulation of gene expression. Their work involves advanced methods like deoxyribozyme assembly and capillary electrophoresis to improve RNA analysis.
mass spectrometryRNA sequencingepitranscriptomicscapillary electrophoresisnucleic acidsbiotherapeuticsRNA modificationstwo-dimensional mass spectrometry
Research Aims
5AIM 01Develop RNA-cleaving deoxyribozymes for mid-down sequencing of large RNAs.
AIM 02Enhance capillary electrophoresis methods for improved RNA analysis.
AIM 03Evaluate two-dimensional mass spectrometry for multiplexing RNA analysis.
AIM 04Identify and overcome limitations in analyzing synthetic and natural nucleic acids.
AIM 05Establish methodologies for analyzing RNA modifications in biotherapeutics.
Skills the Lab Values
mass spectrometrycapillary electrophoresisgel electrophoresisnucleic acid extractionRNA manipulationdeoxyribozyme designhigh-resolution analysisdata interpretationbiochemical assays
Output against the department
Publications160bottom 39% of dept.132nd of 216
this lab
most publishedleast published
Citations4.5kbottom 34% of dept.143rd of 216
this lab
most citedleast cited
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