Washington University in St Louis · NeuroscienceLi Microglia Lab
Qingyun Li · Saint Louis, Missouri
Research Focus
Dr. Qingyun Li's lab focuses on understanding the role of microglial cells in Alzheimer's disease (AD). The lab investigates how specific microglial subsets, particularly those known as disease-associated microglia (DAM), contribute to the pathology of AD. By exploring the origins, genetic regulation, and functions of these microglia, the research aims to uncover potential therapeutic targets to help combat Alzheimer's disease.
microgliaAlzheimer's diseasedisease-associated microgliagene expressionepigenetics
Research Aims
3AIM 01Identify the cellular origin of disease-associated microglia in Alzheimer's disease.
AIM 02Investigate the transcriptional regulation of microglial subsets despite AD pathology.
AIM 03Determine the functional role of disease-associated microglia during Alzheimer's disease progression.
Skills the Lab Values
single-cell RNA sequencinggenetic fate mappingtransplantation of microglial cellsmicroglial cell cultureepigenetic profiling
Output against the department
Publications170top 44% of dept.295th of 671
this lab
most publishedleast published
Citations8.6ktop 45% of dept.300th of 671
this lab
most citedleast cited
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