University of Kansas · PhysiologyNothnick Adenomyosis Lab
Warren B Nothnick · Lawrence, Kansas
Research Focus
Dr. Warren B Nothnick's lab at the University of Kansas Medical Center focuses on understanding adenomyosis, a common and painful uterine condition affecting many women. The research explores how changes in specific molecules, particularly microRNAs and a protein called REST, contribute to the development of this disease. By using human samples and mouse models, the lab aims to uncover the underlying mechanisms that drive adenomyosis, which could lead to improved diagnostics and innovative treatments for patients.
adenomyosismicroRNAstissue remodelingpathogenesisREST proteinendometrial dysfunctioncell migrationwomen's healthmouse modelsreproductive health
Research Aims
5AIM 01Investigate the role of REST in the development of adenomyosis.
AIM 02Identify key microRNAs involved in tissue remodeling associated with adenomyosis.
AIM 03Characterize communication between endometrial and myometrial cells in the context of adenomyosis.
AIM 04Develop novel experimental models to study adenomyosis pathophysiology.
AIM 05Explore potential new therapeutic targets for adenomyosis treatment.
Skills the Lab Values
cell culturemouse modelsin vitro assaysRNA extractionquantitative PCRWestern blottingimmunofluorescencedata analysisgene expression profilingflow cytometry
Output against the department
Publications154top 49% of dept.138th of 286
this lab
most publishedleast published
Citations2.7kbottom 21% of dept.227th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.