University of Washington-Seattle Campus · Microbiology & ImmunologyStetson Immunotherapy Lab
Daniel B Stetson · Seattle, Washington
Research Focus
Dr. Daniel B. Stetson's lab at the University of Washington focuses on enhancing cancer immunotherapy by manipulating the body's immune response to tumors. Specifically, the research investigates a novel pathway that uses DNA repair mechanisms to activate immune responses against tumors, particularly in cases where standard treatments have failed. By using humanized mouse models and other advanced techniques, the lab aims to develop new therapeutic strategies that could lead to more effective treatments for cancer.
cancer immunotherapyDNA-PKantiviral responsetumor microenvironmentSTING signalingimmune responseinflammationhumanized mouse modelsmelanomaimmune checkpoint blockade
Research Aims
4AIM 01Investigate the role of DNA-PK in activating antiviral responses in tumors.
AIM 02Evaluate the effects of DNA-PK activation on immune cell recruitment in melanoma.
AIM 03Test the therapeutic potential of DNA-PK-SIDSP activation in human tumors in vitro and in vivo.
AIM 04Assess how DNA-PK influences responses to foreign DNA versus DNA damage in tumor cells.
Skills the Lab Values
cell culturetumor modelingin vivo studiesimmunohistochemistryflow cytometrymolecular cloningPCRWestern blotRNA extractionhumanized mouse models
Output against the department
Publications81bottom 27% of dept.355th of 486
this lab
most publishedleast published
Citations12ktop 31% of dept.150th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.