Ohio State University-Main Campus · PhysiologyChinthalapudi Lab
Krishna Chinthalapudi · Columbus, Ohio
Research Focus
Dr. Krishna Chinthalapudi's lab at Ohio State University focuses on understanding how proteins in the heart, particularly cardiac myosin and its binding partner cMyBP-C, control muscle contraction. This research aims to uncover the molecular mechanisms behind these proteins, which is crucial for developing new treatments for heart diseases like cardiomyopathy. By exploring the structural states of cardiac myosin, the lab hopes to shed light on how these processes affect heart function and could lead to innovative therapies.
cardiac myosincMyBP-Cmuscle contractioncardiomyopathythick filament regulationmolecular mechanismsstructural biologyheart diseasephosphorylationtherapeutic advancements
Research Aims
3AIM 01Determine the structures of distinct myosin states in a double-headed configuration.
AIM 02Investigate how myosin conformations affect cMyBP-C binding and cardiac thick filament regulation.
AIM 03Examine the in vivo functional consequences of manipulating thick filament structure using small molecules and cMyBP-C phosphorylation.
Skills the Lab Values
Cryoelectron MicroscopyFluorescence Resonance Energy Transferin vitro assaysprotein purificationstructural analysismolecular modelingmyosin binding studiesphosphorylation techniquesbiophysical characterizationanimal models
Output against the department
Publications76bottom 16% of dept.238th of 286
this lab
most publishedleast published
Citations902bottom 3% of dept.278th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.