Texas A&M University-College Station · Biomedical EngineeringOsteochondral Regeneration Lab
Melissa Grunlan · College Station, Texas
Research Focus
Dr. Melissa Grunlan's lab focuses on developing innovative treatments for osteochondral defects, which involve damage to cartilage and bone in joints. They aim to create a bioprosthetic implant that combines a synthetic cartilage cap with a biodegradable bone scaffold to enhance healing and restore joint function. This research is critical for improving patient outcomes in those suffering from joint pain and osteoarthritis.
osteochondral defectsbioprosthetic implantscartilage regenerationbone regenerationhydrogelstissue integrationorthopedicsbiomaterials
Research Aims
5AIM 01Develop a cartilage-capped regenerative osteochondral plug to heal osteochondral defects.
AIM 02Create a synthetic cartilage cap that mimics the properties of native cartilage.
AIM 03Design a biodegradable scaffold to promote bone formation and tissue integration.
AIM 04Evaluate the in vitro behavior of human bone marrow stem cells on the scaffold.
AIM 05Assess the in vivo performance of the implant in a rabbit model for joint defects.
Skills the Lab Values
hydrogel fabrication3D printing of scaffoldscell culture techniquesbiomechanical testinghistologymicro-CT imagingin vivo animal modelsbiocompatibility assessment
Output against the department
Publications151bottom 33% of dept.397th of 595
this lab
most publishedleast published
Citations4.2kbottom 32% of dept.403rd of 595
this lab
most citedleast cited
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