Ohio State University-Main Campus · PharmacologyHu Lab
Shuiying Hu · Columbus, Ohio
Research Focus
Dr. Shuiying Hu's lab at Ohio State University focuses on understanding how the chemotherapy drug vincristine causes damage to peripheral neurons and finding ways to prevent this neurotoxicity. The lab studies how vincristine is taken up by neurons through specific transporters and aims to develop drugs that can protect these neurons while still allowing vincristine to effectively target cancer cells. Their research could lead to safer cancer treatments with fewer side effects for patients.
vincristineneurotoxicitychemotherapyneuropathic painOATP transportersdrug developmentcancer treatmentbiomarkers
Research Aims
3AIM 01Investigate the role of OATP1B2/3 transporters in vincristine accumulation in neurons.
AIM 02Develop pharmacological inhibitors to reduce neurotoxicity without affecting vincristine efficacy.
AIM 03Use biomarkers to optimize dosing of inhibitors in animal models.
Skills the Lab Values
cell cultureanimal modelspharmacologydrug screeningmolecular biology techniquesbiomarker validationdata analysisexperimental design
Output against the department
Publications346top 20% of dept.94th of 462
this lab
most publishedleast published
Citations4.9kbottom 36% of dept.295th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.