UWMUniversity of Wisconsin-Madison · Biology
Alzheimer's Therapeutics and Microbiome Lab
Tyler Kent Ulland · Madison, Wisconsin
Research Focus
Dr. Ulland's lab focuses on understanding how a substance called beta-hydroxybutyrate (BHB) can impact the progression of Alzheimer's disease. They explore how BHB may alter brain pathology and cognition through its effects on the microbiome and immune response. This research is aimed at uncovering new therapeutic strategies to help combat Alzheimer's disease, which affects many older adults.
Alzheimer's diseasebeta-hydroxybutyratemicrobiomeinflammasomecognitive function
Research Aims
5AIM 01Investigate how BHB alters Alzheimer's disease pathology in mouse models.
AIM 02Determine the role of the gut microbiome in influencing BHB levels.
AIM 03Examine how BHB affects the inflammasome in microglial cells.
AIM 04Assess the correlation between gut microbiome composition and Alzheimer's disease biomarkers.
AIM 05Explore therapeutic avenues for Alzheimer's disease through BHB supplementation.
Skills the Lab Values
cell culturemouse modelsbehavioral testingPCRmetagenomics
Output against the department
Publications99bottom 35% of dept.673rd of 1,033
this lab
most publishedleast published
Citations14ktop 26% of dept.272nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.