University of Utah · BiochemistrySundquist Lab
Wesley I. Sundquist · Salt Lake City, Utah
Research Focus
The lab of Dr. Wesley I. Sundquist at the University of Utah focuses on understanding the molecular mechanisms behind HIV-1 virus assembly and release from host cells. By studying the roles of specific host proteins and cellular pathways, the research aims to identify how HIV-1 exploits these mechanisms and how certain proteins can inhibit viral release. This research not only targets HIV but also provides insights into other enveloped viruses and potential therapeutic strategies against viral infections.
HIV-1viral assemblyESCRT machinerymembrane fissionviral envelopment
Research Aims
3AIM 01Investigate how assembling HIV-1 virions are wrapped in cellular membranes.
AIM 02Characterize the role of ESCRT machinery in viral membrane constriction and budding.
AIM 03Explore how truncated CHMP3 proteins can inhibit the release of HIV-1 without harming host cells.
Skills the Lab Values
PCRcell culturemolecular cloningbiochemical assaysimaging techniquesgenetic manipulationbiophysical characterizationcryoelectron microscopyprotein-protein interaction studieslive-cell imaging
Output against the department
Publications233top 33% of dept.130th of 402
this lab
most publishedleast published
Citations28ktop 13% of dept.51st of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.