MCWMedical College of Wisconsin · Physiology
Liu Lab
Chun Liu · Milwaukee, Wisconsin
Research Focus
Dr. Chun Liu's lab focuses on understanding how chemotherapy drugs, particularly anthracyclines like doxorubicin, can harm the heart of cancer survivors. They study a protein called Carbonic Anhydrase XII and its role in heart disease caused by these drugs. By using advanced cell models and genetic techniques, their research aims to uncover new ways to protect the heart, potentially leading to safer cancer treatments.
cardiotoxicityanthracyclinescarbonic anhydrase XIIglycolysisepigeneticscardiomyocyteschemotherapycardioprotective strategieshuman stem cellscancer survivorship
Research Aims
3AIM 01Investigate how inhibiting Carbonic Anhydrase XII protects against heart damage from anthracycline chemotherapy.
AIM 02Explore the link between increased lactate production and histone lactylation in heart cells.
AIM 03Develop a better understanding of how metabolic processes affect heart health in cancer survivors.
Skills the Lab Values
CRISPR interferencecell culturegenetic screeningmouse modelsepigenetic analysisbioinformaticsinduced pluripotent stem cellsWestern blotreal-time PCRmetabolic assays
Output against the department
Publications356top 10% of dept.30th of 286
this lab
most publishedleast published
Citations4.0kbottom 32% of dept.194th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.