Iowa State University · BiochemistryNeuroimmune Interaction Laboratory
Chen Gu · Ames, Iowa
Research Focus
Dr. Chen Gu's lab at Ohio State University focuses on understanding how certain ion channels influence both the immune response and neuron function in the central nervous system (CNS). By studying the interactions between T cells and neurons, particularly in conditions like multiple sclerosis, the lab aims to identify new strategies for neuroprotection and repair that could help address inflammatory demyelinating disorders. They employ a variety of advanced techniques to delve into these complex biological processes.
CNS autoimmunitymultiple sclerosision channelsT cell activationaxonal injury
Research Aims
3AIM 01Investigate how Kv3 channels affect T cell activation in CNS autoimmunity.
AIM 02Explore the impact of Kv3 channels on axonal injury in autoimmune conditions.
AIM 03Examine the interactions between T cells and neurons through Kv3 channel regulation.
Skills the Lab Values
mouse modelsflow cytometryRNA interferencecell cultureconfocal microscopytransmission electron microscopyfunctional assaysgenetic engineeringimmunostainingdata analysis