University of California-San Francisco · PharmacologyManglik Lab
Aashish Manglik · San Francisco, California
Research Focus
Dr. Aashish Manglik's lab at UCSF focuses on understanding how our sense of smell works. They study specific proteins called odorant receptors, which allow us to detect various smells. By analyzing the structure and function of these receptors, the lab aims to uncover the mechanisms of smell perception, which could lead to new treatments for smell-related disorders.
odorant receptorsolfactionG protein-coupled receptorsstructural biologymolecular dynamics
Research Aims
3AIM 01Identify features of odorant receptors responsible for odorant selectivity.
AIM 02Reveal differences in odorant recognition between Class I and Class II receptors.
AIM 03Describe the mechanisms by which odorants activate receptors.
Skills the Lab Values
cryoelectron microscopymolecular dynamics simulationsiterative mutagenesisprotein structure determinationbioinformatics
Output against the department
Publications177bottom 48% of dept.238th of 462
this lab
most publishedleast published
Citations19ktop 20% of dept.91st of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.