Ohio State University-Main Campus · GeneticsBurd Lab
Christin E Burd · Columbus, Ohio
Research Focus
Dr. Christin Burd's lab at Ohio State University studies how specific mutations in the NRAS gene lead to various types of cancer, focusing primarily on melanoma and other malignancies. The lab examines the unique biochemical behaviors of different NRAS mutant proteins, seeking to understand how these differences affect tumor growth and response to treatments. By leveraging a combination of structural biology and experimental approaches, the lab aims to identify potential new therapeutic targets for RAS-driven cancers.
NRASmelanomatumorigenesiscancer biologydrug targeting
Research Aims
3AIM 01Investigate the structural properties of NRAS mutants using advanced imaging techniques.
AIM 02Determine how NRAS mutations influence BRAF activation in cancer cells.
AIM 03Test therapies that could prevent NRAS-driven melanoma by targeting specific signaling pathways.
Skills the Lab Values
X-ray crystallographyNMR spectroscopybiochemical assayslive-cell imagingmouse modelsprotein purificationWestern blotdata analysisexperimental design
Output against the department
Publications142bottom 46% of dept.138th of 259
this lab
most publishedleast published
Citations12ktop 45% of dept.116th of 259
this lab
most citedleast cited
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