Michigan State University · PharmacologyBladder Sensation and Mechanics Lab
Nathan Roger Tykocki · East Lansing, Michigan
Research Focus
Dr. Nathan Tykocki's lab focuses on understanding how our bladder feels full as it fills with urine. They study the mechanical properties of the bladder wall and how these properties influence our sensation of needing to void. By using advanced techniques from both engineering and physiology, the lab aims to uncover the connection between bladder mechanics and sensory nerve signaling, which could lead to better treatments for bladder dysfunction.
bladder mechanicssensation of fullnessbladder dysfunctionneurophysiologybiomechanics
Research Aims
5AIM 01Investigate how bladder wall biomechanics affect perception of fullness.
AIM 02Define the microstructural changes in bladder wall as it fills with urine.
AIM 03Analyze the role of smooth muscle contractions in sensory outflow.
AIM 04Understand the connection between bladder mechanics and central nervous system signaling.
AIM 05Elucidate the relationship between bladder elasticity, viscosity, and sensory response.
Skills the Lab Values
3-Dimensional imagingBiomechanical modelingMouse modelsHistologyOptogenetics
Output against the department
Publications73bottom 16% of dept.388th of 462
this lab
most publishedleast published
Citations1.4kbottom 8% of dept.424th of 462
this lab
most citedleast cited
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