University of Virginia-Main Campus · BiochemistryStukenberg Lab
P. Todd Stukenberg · Charlottesville, Virginia
Research Focus
The Stukenberg lab at the University of Virginia focuses on understanding how chromosomes are accurately separated during cell division, a process that goes awry in many cancers. They have discovered that a protein complex called the Chromosome Passenger Complex, which includes Aurora B kinase, is crucial for this regulation and can form special structures that help with this accuracy. Their research aims to uncover the molecular mechanisms behind these processes and explore new cancer therapies based on their findings.
mitotic regulationAurora B kinaseaneuploidychromosome segregationgenomic instabilitycancer therapytranscription regulationmicrotubule bundlingliquid-liquid phase separation
Research Aims
5AIM 01Investigate how the Chromosome Passenger Complex ensures accurate chromosome segregation during mitosis.
AIM 02Elucidate the role of Aurora B kinase in regulating transcription at the centromere.
AIM 03Explore how dysregulation of the CPC contributes to aneuploidy in cancer cells.
AIM 04Develop new tools to study mitotic processes through reconstitution and modeling.
AIM 05Identify potential therapeutic strategies targeting Aurora B in cancer treatment.
Skills the Lab Values
cell cultureprotein purificationin vitro assaysplasmid constructionCRISPRmicroscopytranscription analysisin silico modelingfluorescence imaging
Output against the department
Publications140bottom 40% of dept.241st of 402
this lab
most publishedleast published
Citations15ktop 31% of dept.125th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.