AECAlbert Einstein College of Medicine · Biology
The Nucleolus Nexus
U Thomas Meier · Bronx, New York
Research Focus
Dr. U Thomas Meier's lab focuses on how the nucleolus, a crucial part of the cell that produces ribosomes, works and how its dysfunction can lead to diseases like dyskeratosis congenita. The team investigates the processes involved in ribosomal RNA modification, aiming to understand how these processes contribute to diseases and finding potential therapeutic interventions. This research could unveil new treatment strategies for patients with blood cell production disorders.
ribosome biogenesisRNA modificationdyskeratosis congenitanucleolusphase separationsnoRNPmolecular chaperonesRNA polymerase I
Research Aims
3AIM 01Determine how the dense fibrillar component of the nucleolus forms.
AIM 02Identify the mechanism of cotranscriptional RNA modification.
AIM 03Define the impact of dyskeratosis congenita on ribosome synthesis.
Skills the Lab Values
cell cultureelectron microscopyfluorescence microscopyRNA extractionPCRmolecular cloningWestern blottinggenomic analysisbioinformaticsin vitro assays
Output against the department
Publications82bottom 25% of dept.774th of 1,033
this lab
most publishedleast published
Citations4.3kbottom 33% of dept.688th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.