Duke University · PsychologyBiological Aging and Biomarkers Lab
Terrie E Moffitt · Durham, North Carolina
Research Focus
Terrie E Moffitt's lab at Duke University focuses on understanding biological aging through a novel measurement tool called DunedinPoAm4x. By analyzing blood samples and studying numerous physiological biomarkers over decades, the lab aims to pinpoint how quickly individuals age biologically compared to their chronological age. Their research seeks to improve aging assessments and explore how lifestyle changes and genetic factors can influence the pace of aging.
biological agingDunedinPoAm4xDNA methylationhealth interventionsaging biomarkersmachine learningcognitive declinefrailtydisease predictionstructural brain aging
Research Aims
5AIM 01Validate the DunedinPoAm4x as a reliable measure of biological aging.
AIM 02Investigate the relationship between DunedinPoAm4x scores and cognitive decline.
AIM 03Assess the impact of adverse childhood experiences on biological aging.
AIM 04Examine how lifestyle changes can affect the pace of biological aging.
AIM 05Compare DunedinPoAm4x with existing methylation clocks in various populations.
Skills the Lab Values
machine learningbiomarker analysisDNA extractiondata modelingstatistical analysisblood sample processingbioinformaticsphysiological measurementlongitudinal study designdatabase management
Output against the department
Publications926top 1% of dept.4th of 296
this lab
most publishedleast published
Citations193ktop 1% of dept.1st of 296
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.