University of Rochester · BiochemistryRNA Structure Prediction Lab
David H. Mathews · Rochester, New York
Research Focus
The Mathews lab at the University of Rochester focuses on understanding RNA molecules, which play crucial roles in biology and can be used in pharmaceuticals. They work on developing software and algorithms to predict RNA structures, which are vital for their functions. By studying these structures, the lab aims to contribute to our understanding of disease mechanisms and the development of RNA-based drugs.
RNA modelingbiophysical principlesstructure predictionsoftware developmentexperimental mapping
Research Aims
5AIM 01Develop algorithms for RNA structure prediction.
AIM 02Create software for analyzing RNA structures.
AIM 03Incorporate experimental data into RNA models.
AIM 04Collaborate with experimentalists to validate predictions.
AIM 05Provide software to the scientific community.
Skills the Lab Values
RNA structure modelingalgorithm developmentsoftware testingcollaborative researchbiophysical analysis
Output against the department
Publications286top 24% of dept.95th of 402
this lab
most publishedleast published
Citations22ktop 18% of dept.74th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.