University of Pennsylvania · PhysiologyCalcium Transfer in Pancreatic Cancer Lab
James Kevin Foskett · Philadelphia, Pennsylvania
Research Focus
The lab focuses on understanding the role of calcium transfer from the endoplasmic reticulum to mitochondria in the development and spread of pancreatic cancer. By using advanced cell and animal models, the research aims to uncover new therapeutic targets that could improve treatment outcomes for this aggressive cancer. The lab employs various techniques to investigate metabolic processes and how they relate to cancer cell survival and metastasis.
pancreatic cancercalcium transfermetastasistumor maintenanceER-to-mitochondria communication
Research Aims
5AIM 01Examine the role of calcium transfer in pancreatic cancer development.
AIM 02Investigate how mitochondrial calcium uptake influences cancer cell survival.
AIM 03Identify novel therapeutic targets in pancreatic cancer.
AIM 04Evaluate the metastatic potential of pancreatic cancer cells in vivo.
AIM 05Determine the effects of acute calcium channel inhibition on tumor maintenance.
Skills the Lab Values
cell cultureanimal modelsCRISPR/Cas9live-cell imagingelectrophysiologybiochemical assaysfluorimetrytranswell invasion assaysgene modification
Output against the department
Publications1bottom 1% of dept.285th of 286
this lab
most publishedleast published
Citations19bottom 1% of dept.284th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.