Drexel University · Microbiology & ImmunologyMalaria mRNA Initiative
James Matthew Burns · Philadelphia, Pennsylvania
Research Focus
Dr. James Matthew Burns' lab focuses on developing innovative malaria vaccines using advanced mRNA technology. The research aims to create a multivalent vaccine that targets different stages of malaria parasites, potentially providing better protection against the disease. This involves understanding immune responses and optimizing vaccine formulations to enhance effectiveness.
mRNA vaccinesmalariaPlasmodiumimmune responsevaccine development
Research Aims
5AIM 01Develop a multivalent mRNA-based malaria vaccine to target various stages of the parasite.
AIM 02Optimize immune responses to both pre-erythrocytic and blood-stage malaria vaccine candidates.
AIM 03Evaluate the efficacy of mRNA technology in producing a multi-component malaria vaccine.
AIM 04Test different formulations to enhance durability of vaccine-induced protection.
AIM 05Investigate the potential of targeting multiple antigens in a single vaccine.
Skills the Lab Values
recombinant protein productionadjuvant formulationcell cultureimmunogenicity testingantibody titer measurementPCRdata analysisvaccine designanimal modelsflow cytometry