UCUniversity of Cincinnati-Main Campus · Microbiology & Immunology
Thompson Lab
Thomas B Thompson · Cincinnati, Ohio
Research Focus
Dr. Thomas B Thompson's lab at the University of Cincinnati focuses on understanding the TGF-beta family of signaling molecules and how they regulate critical biological processes such as fetal development and adult health. Using cutting-edge techniques from structural biology, biophysics, and computational methods, the lab aims to uncover the details of how these molecules interact and function, which is crucial for developing new therapies for diseases like cancer and cardiovascular issues.
TGF-betasignal transductionstructural biologyproteinsdisease mechanisms
Research Aims
4AIM 01Investigate ligand-receptor interactions for selectivity.
AIM 02Understand how prodomains regulate their ligands.
AIM 03Explore the formation and interaction differences between heterodimers and homodimers.
AIM 04Characterize how antagonists bind and modulate ligands.
Skills the Lab Values
cryo-electron microscopyX-ray crystallographyprotein engineeringcell-based assayscomputational biology
Output against the department
Publications141top 46% of dept.223rd of 486
this lab
most publishedleast published
Citations5.2kbottom 39% of dept.298th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.