University of Michigan-Ann Arbor · PhysiologyThe Metabolism Circuit Lab
Liangyou Rui · Ann Arbor, Michigan
Research Focus
Dr. Liangyou Rui's lab focuses on understanding the role of specific brain circuits in regulating body weight and metabolism, particularly in the context of obesity and metabolic diseases. The lab investigates how SH2B1, a signaling protein, influences these neural pathways and how disruptions can lead to disorders such as type 2 diabetes and fatty liver disease. Their research aims to develop new therapeutic strategies for treating obesity by mapping these intricate neurocircuits.
metabolic diseaseobesitybrain circuitsSH2B1neuroscienceenergy balanceBDNFtype 2 diabetesphosphorylationneurotransmitters
Research Aims
3AIM 01Map the circuits mediated by PVHSH2B1 neurons to determine their role in SH2B1 protection against obesity.
AIM 02Investigate how the BDNF/TrkB/SH2B1 pathway regulates PVHSH2B1 neuron function.
AIM 03Examine how SH2B1 phosphorylation affects obesity and its related variants in human populations.
Skills the Lab Values
optogeneticsgenetic mouse modelspharmacological assaysneuroscience techniquesimmunohistochemistryWestern blotcell culturedata analysisphysiological measurements
Output against the department
Publications135bottom 44% of dept.160th of 286
this lab
most publishedleast published
Citations11ktop 28% of dept.79th of 286
this lab
most citedleast cited
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