Northwestern University · PhysiologyCognitive Neuroscience and Chloride Transport Lab
Marco Martina · Evanston, Illinois
Research Focus
Dr. Marco Martina's lab focuses on understanding how imbalances in brain signaling might contribute to cognitive impairments and social interaction challenges in psychiatric disorders, particularly schizophrenia. They investigate neuronal mechanisms using different rodent models to explore how shifts in chloride transport can affect cognition. Through this research, they aim to find ways to restore cognitive function using existing medications, thus paving the way for potential new treatments for psychiatric conditions.
schizophreniaGABA signalingrodent modelscognitive impairmentchloride transport
Research Aims
3AIM 01Investigate GABAA current reversal potential in mPFC neurons using electrophysiological techniques.
AIM 02Assess cognitive impairment caused by increased NKCC1/KCC2 ratio in mPFC neurons.
AIM 03Evaluate the cognitive benefits of NKCC1 inhibition across multiple genetic models of schizophrenia.
Skills the Lab Values
perforated patch recordingsin situ hybridizationbehavioral assessmentpharmacological manipulationgenetic manipulation
Output against the department
Publications72bottom 15% of dept.243rd of 286
this lab
most publishedleast published
Citations4.0kbottom 33% of dept.192nd of 286
this lab
most citedleast cited
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