University of Kentucky · PharmacologyInflammation and Aging Research Group
Barbara Nikolajczyk · Lexington, Kentucky
Research Focus
Dr. Barbara Nikolajczyk's lab at the University of Kentucky focuses on understanding how inflammation affects aging and overall health. They study the drug everolimus, which targets specific pathways involved in inflammation, to see if it can improve health as we age. The lab's research combines clinical trials and laboratory techniques to explore how reducing inflammation can enhance the quality of life in older adults.
inflammationagingmTOReverolimusimmune cellshealthspanchronic diseaseT cellsmetabolismbioenergetics
Research Aims
5AIM 01Investigate how everolimus affects inflammation in immune cells.
AIM 02Evaluate the impact of low doses of everolimus on health in older adults.
AIM 03Analyze the relationship between inflammation and aging in clinical trial subjects.
AIM 04Determine safety and efficacy of everolimus for improving healthspan.
AIM 05Explore the differences in effect of everolimus on immune cells compared to muscle cells.
Skills the Lab Values
cell cultureflow cytometryconfocal microscopyRNA sequencinganimal modelscytokine profilingdrug dosingbiochemical assaysdata analysisexperimental design
Output against the department
Publications123bottom 35% of dept.298th of 462
this lab
most publishedleast published
Citations6.2kbottom 44% of dept.258th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.