University of Texas Southwestern Medical Center · NeuroscienceCircadian Metabolism Research Lab
Carla B. Green · Dallas, Texas
Research Focus
Carla B. Green's lab focuses on understanding how the body's internal clocks regulate metabolism and contribute to health. They study a protein called Nocturnin, which plays a key role in processing certain molecules that influence metabolic functions. By examining specific gene functions in mice, they hope to uncover how disruptions in circadian rhythms can lead to obesity and other metabolic diseases, aiming to find potential treatments for related health issues.
circadian rhythmsmetabolismNocturninhigh-fat dietgene expressionobesityhepatic steatosisNADP(H)metabolomics
Research Aims
4AIM 01Investigate the tissue-specific roles of Nocturnin in metabolism.
AIM 02Determine how loss of Nocturnin affects body weight and energy expenditure.
AIM 03Examine gene expression changes in Nocturnin knockout mice on a high-fat diet.
AIM 04Understand the molecular mechanisms of Nocturnin's impact on obesity and liver health.
Skills the Lab Values
mouse modelsconditional knockoutenergy expenditure assessmentmetabolic cage analysisgene expression analysishistological techniquesbioinformaticsdrug screening techniqueslipid profilingmetabolic flux analysis
Output against the department
Publications110bottom 38% of dept.412th of 671
this lab
most publishedleast published
Citations12ktop 35% of dept.235th of 671
this lab
most citedleast cited
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