Johns Hopkins University · Biomedical EngineeringCerebrovascular and Cognitive Health Lab
Zhiliang Wei · Baltimore, Maryland
Research Focus
Dr. Zhiliang Wei's lab at Johns Hopkins University focuses on understanding how reduced blood flow in the brain, known as hypoperfusion, affects Alzheimer's disease and related dementias. By using advanced MRI techniques and mouse models, the lab aims to explore how blood flow interacts with brain metabolism and cognitive functions. This research is crucial for identifying new biomarkers and treatments for dementia, enhancing the understanding of the disease mechanisms.
hypoperfusionAlzheimer's diseasesmall vessel diseasecerebrovascular reactivitybrain metabolismMRI techniquesmouse modelsdementianeurovascular function
Research Aims
4AIM 01Investigate the relationship between hypoperfusion and cognitive deficits in Alzheimer's disease.
AIM 02Characterize vascular and metabolic dysfunctions in small vessel disease mouse models.
AIM 03Develop a mechanistic model to understand the interactions between blood flow and brain health.
AIM 04Conduct longitudinal studies to observe changes over time in hypoperfusion-related parameters.
Skills the Lab Values
MRI imaging techniquesanimal modelsbehavioral assaysimmunohistochemistrycerebrovascular analysisdata collectionlongitudinal studiesbiomarker identificationstatistical analysis
Output against the department
Publications129bottom 26% of dept.439th of 595
this lab
most publishedleast published
Citations2.1kbottom 15% of dept.506th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.