Northwestern University · NeuroscienceOzdinler Lab
Pembe Hande Ozdinler · Evanston, Illinois
Research Focus
Dr. Pembe Hande Ozdinler's lab focuses on developing new treatment strategies for neurodegenerative diseases like Alzheimer's and frontotemporal dementia. Their key compound, NU-9, shows promise in reducing harmful protein aggregation and improving neuron health. The lab explores how NU-9 works at a cellular level, aiming to enhance neuronal function, survival, and overall brain health through innovative drug discovery.
Alzheimer's Diseasefrontotemporal dementiaprotein aggregationneurodegenerationdrug discoverycellular mechanismsaxon outgrowthFDA approved drugs
Research Aims
5AIM 01Investigate the mode of action of NU-9 on neuronal health in Alzheimer's disease.
AIM 02Evaluate how NU-9 can reduce protein aggregation in neurodegenerative conditions.
AIM 03Explore the development of new NU-9 derivatives for improved efficacy.
AIM 04Examine the impact of NU-9 on axon outgrowth and neuronal survival.
AIM 05Identify cellular targets affected by NU-9 in neurodegenerative diseases.
Skills the Lab Values
cell culturemouse modelsbiological assaysWestern blotRNA sequencingmicroscopydata analysisprotein inhibition techniquesmolecular biologyclinical trial design
Output against the department
Publications2bottom 1% of dept.663rd of 671
this lab
most publishedleast published
Citations6bottom 1% of dept.661st of 671
this lab
most citedleast cited
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