University of Texas Southwestern Medical Center · BiochemistryGlycoconjugate Research Laboratory
Jennifer J Kohler · Dallas, Texas
Research Focus
Dr. Jennifer Kohler's lab at UT Southwestern Medical Center studies glycoconjugates, which are complex sugar molecules found on cell surfaces. They explore how these molecules interact with pathogens like cholera toxin and how they vary from person to person, potentially influencing diseases and infection vulnerability. The lab develops innovative chemical biology tools to investigate these questions, helping to further our understanding of cell biology and disease processes.
glycoconjugatesglycosylationcholera toxinchemical biologyCRISPR screeninghost-microbe interactionsdisease associationsugar analogscell surface binding
Research Aims
5AIM 01Investigate the biological roles of glycoconjugates on cell surfaces.
AIM 02Develop new chemical biology tools for glycoscience research.
AIM 03Identify genes involved in the regulation of glycosylation.
AIM 04Characterize the interaction of cholera toxin with fucosylated glycoconjugates.
AIM 05Explore how variations in glycosylation impact disease susceptibility.
Skills the Lab Values
photocrosslinking techniquescell cultureglycan-binding assaysCRISPR gene editingmolecular structure analysisbiochemical methodsmicroscopydata interpretationprotein analysis
Output against the department
Publications108bottom 27% of dept.292nd of 402
this lab
most publishedleast published
Citations3.6kbottom 19% of dept.327th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.