UCUniversity of Cincinnati-Main Campus · Pharmacology
Karthickeyan Lab
Karthickeyan Chella Krishnan · Cincinnati, Ohio
Research Focus
Dr. Karthickeyan Chella Krishnan's lab at the University of Cincinnati focuses on understanding how a liver gene called L-PK influences cholesterol metabolism and the development of atherosclerosis, particularly in a sex-specific context. By using a range of advanced techniques, the lab investigates how variations in L-PK affect liver function and lipid levels, which are crucial for preventing metabolic diseases. The research aims to uncover potential therapeutic targets for managing cholesterol-related health issues.
cholesterol metabolismatherosclerosissex-specific researchliver genehyperlipidemiamitochondrial function
Research Aims
4AIM 01Investigate how L-PK affects hepatic cholesterol synthesis, secretion, and clearance.
AIM 02Identify sex-specific pathways that regulate plasma cholesterol levels via L-PK.
AIM 03Examine the role of L-PK in liver triglyceride accumulation and mitochondrial function.
AIM 04Clarify how L-PK modulates atherosclerosis progression in males and females.
Skills the Lab Values
genomic analysistranscriptomic profilinglipidomic studiesanimal modelinggonadectomy techniquesbioenergetic assayselevated triglyceride measurementmetabolic disease assessment
Output against the department
Publications50bottom 7% of dept.431st of 462
this lab
most publishedleast published
Citations1.4kbottom 8% of dept.425th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.