Rowan University · ChemistrySignaling Nexus Lab
Zhihong Wang · Glassboro, New Jersey
Research Focus
Dr. Zhihong Wang's lab at Rowan University studies a protein complex that regulates important signaling pathways involved in cell growth and development. The research focuses on understanding how this complex is formed and how it functions in healthy and diseased cells. By developing new chemical tools, the lab aims to explore potential treatments for various cancers and genetic disorders that arise from disruptions in these signaling pathways.
RAS-MAPK signalingprotein complexcell proliferationtherapeutic interventionchemical probes
Research Aims
5AIM 01Investigate the assembly and function of the MRAS-SHOC2-PP1C complex.
AIM 02Elucidate the structural basis of how the complex regulates RAS signaling.
AIM 03Develop chemical probes to disrupt the functioning of the SMP complex.
AIM 04Assess the consequences of SMP complex disruption in cellular models.
AIM 05Explore therapeutic strategies targeting RAS-driven malignancies.
Skills the Lab Values
structural biologybiochemical assayschemical biologycomputational simulationsbiophysical techniquescellular assayscryoelectron microscopydrug designprotein purification
Output against the department
Publications387top 28% of dept.61st of 216
this lab
most publishedleast published
Citations5.8kbottom 40% of dept.129th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.