University of Rochester · Microbiology & ImmunologyDunman Lab
Paul M. Dunman · Rochester, New York
Research Focus
Dr. Paul M. Dunman's research lab at the University of Rochester focuses on tackling the critical issue of antibiotic resistance, specifically in the bacterium Acinetobacter baumannii. The lab studies how this pathogen develops resistance through various drug efflux pumps, which can pump out antibiotics and render them ineffective. By identifying and developing inhibitors that can block these efflux pumps, the lab aims to enhance the efficacy of existing antibiotics and combat multi-drug resistant infections in clinical settings.
antibiotic resistanceefflux pumpsAcinetobacter baumanniidrug discoveryhigh throughput screening
Research Aims
5AIM 01Identify broad-spectrum efflux pump inhibitors for A. baumannii.
AIM 02Expand screening to include diverse chemical libraries.
AIM 03Optimize benzenesulfonamide efflux pump inhibitors.
AIM 04Define cellular targets of new efflux pump inhibitors.
AIM 05Test efficacy of candidate compounds in vivo.
Skills the Lab Values
high throughput screeningmedicinal chemistrydrug efficacy testingmicrobial culturingantibiotic susceptibility testing
Output against the department
Publications151top 43% of dept.210th of 486
this lab
most publishedleast published
Citations11ktop 34% of dept.163rd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.