Yale University · Microbiology & ImmunologyCaron Lab
Etienne Caron · New Haven, Connecticut
Research Focus
Dr. Etienne Caron's lab at Yale University focuses on uncovering how the immune system can be better harnessed to fight cancer, particularly through the analysis of tumor-specific antigens (TSAs) and self-peptides. By using advanced mass spectrometry and digital microfluidics, the lab aims to develop innovative methods for the rapid identification of key immune targets from small tissue samples, thus paving the way for personalized cancer immunotherapy. Their research challenges traditional views on T cell activation, suggesting that self-peptides play a crucial role in immune regulation.
cancer immunotherapymass spectrometryself-immunopeptidomedigital microfluidicsT cell activationimmunopeptidomicspersonalized medicinerobotics in biologyartificial intelligencemachine learning
Research Aims
5AIM 01Develop a digital microfluidics platform for efficient isolation of tumor-specific antigens.
AIM 02Investigate the regulatory roles of self-peptides in T cell activation.
AIM 03Utilize mass spectrometry to analyze the self-immunopeptidome across various tissues.
AIM 04Employ machine learning to predict T cell responses based on peptide interactions.
AIM 05Explore applications of regulatory self-peptides in enhancing CAR T cell therapies.
Skills the Lab Values
mass spectrometrydigital microfluidicscell cultureT cell assaysrobotic automationdata analysis with Pythonliquid chromatographymachine learningimmunotherapy techniquespeptide synthesis
Output against the department
Publications138top 47% of dept.226th of 486
this lab
most publishedleast published
Citations5.4kbottom 40% of dept.294th of 486
this lab
most citedleast cited
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