University of Pennsylvania · BiologyEpstein Immunotherapy Lab
Jonathan A. Epstein · Philadelphia, Pennsylvania
Research Focus
Dr. Jonathan A. Epstein's lab at the University of Pennsylvania focuses on designing advanced immune therapies to improve cardiac health. Specifically, the research targets the engineering of T regulatory cells to combat inflammation and fibrosis in the heart after events such as myocardial infarction, which can lead to heart failure. Through innovative techniques like lipid nanoparticle delivery, the lab aims to enhance the healing process and overall heart function.
CAR T-regulatory cellsmyocardial infarctioncardiac fibrosisinflammationheart failureimmunoengineeringcell therapytargeted therapy
Research Aims
4AIM 01Develop CAR Tregs to target activated fibroblasts in the heart.
AIM 02Investigate the effects of engineered immune cells on cardiac inflammation.
AIM 03Test the safety and efficacy of Treg therapy in mouse models of heart disease.
AIM 04Optimize methods for in vivo engineering of T regulatory cells.
Skills the Lab Values
cell cultureanimal modelslipid nanoparticle deliverymRNA engineeringflow cytometrycytokine analysisPCRWestern blotimmunophenotyping
Output against the department
Publications387top 12% of dept.124th of 1,033
this lab
most publishedleast published
Citations36ktop 8% of dept.87th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.