University of Maryland, Baltimore · PharmacologyThe Estrogen Escape Lab
Min Yu · Baltimore, Maryland
Research Focus
The lab of Min Yu at the University of Maryland Baltimore focuses on understanding how estrogen receptor mutations in breast cancer cells contribute to the disease's progression and metastasis. They study the role of androgen receptors, particularly how they help cancer cells survive during stressful conditions like treatment with aromatase inhibitors. The ultimate goal is to identify new therapeutic strategies for metastatic breast cancer, which is a major challenge for patients.
breast cancermetastasisandrogen receptorestrogen receptoraromatase inhibitorsreactive oxygen speciestherapy resistancecancer signalingpatient-derived xenografts
Research Aims
3AIM 01Investigate how androgen receptor signaling affects the survival of estrogen receptor mutant breast cancer cells during estrogen deprivation.
AIM 02Assess the impact of androgen receptor inhibition on the metastatic potential of breast cancer cells in vivo.
AIM 03Examine how reactive oxygen species levels are influenced by androgen receptor activity in anchorage-independent conditions.
Skills the Lab Values
cell culturemouse modelsin vitro assaysmolecular cloningWestern blotimmunohistochemistryRNA sequencingflow cytometryCRISPRpatient-derived cell line development
Output against the department
Publications363top 19% of dept.85th of 462
this lab
most publishedleast published
Citations21ktop 16% of dept.73rd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.