Georgetown University · BiologyAuditory Synaptic Development Lab
Thomas M Coate · Washington, District of Columbia
Research Focus
Dr. Thomas M. Coate's lab at Georgetown University focuses on understanding how important connections form between nerve cells and hair cells in the inner ear, which are crucial for hearing. The team investigates neural signaling and the role of specific genes in developing these connections, especially in the context of hearing loss and potential therapies for cochlear damage. By studying the molecular mechanisms involved, the lab aims to find new ways to restore hearing capabilities.
cochlear developmentauditory systemsynaptic connectivityspontaneous activityinner hair cells
Research Aims
3AIM 01Investigate the role of POU3F4 and otic mesenchyme cells in generating prehearing spontaneous activity.
AIM 02Define how SEMA5A inhibits spontaneous activity in spiral ganglion neurons.
AIM 03Examine how POU3F4 promotes innervation of inner hair cells.
Skills the Lab Values
Ca2+ imagingmolecular profilingtissue cultureelectrophysiologygene expression analysis
Output against the department
Publications38bottom 6% of dept.962nd of 1,033
this lab
most publishedleast published
Citations871bottom 4% of dept.995th of 1,033
this lab
most citedleast cited
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