University of Virginia-Main Campus · BiologyMalaria Safety and Enzyme Mechanisms Unit
Adam N. Goldfarb · Charlottesville, Virginia
Research Focus
Dr. Adam N. Goldfarb's lab focuses on understanding how certain anti-malarial drugs, like primaquine, interact with red blood cells in individuals who have a genetic deficiency known as G6PD deficiency. This condition affects millions and can lead to severe anemia when taking medications that are otherwise effective against malaria. By studying specific enzymes involved in this process using genetically modified mice, the lab aims to identify better treatment strategies that could reduce harmful side effects in affected patients.
G6PD deficiencyprimaquinehemolytic anemiaredox biologyreactive oxygen speciestransgenic miceenzyme mechanismsmalaria curedrug safety
Research Aims
3AIM 01Identify the role of NQO1 in primaquine-induced hemolysis
AIM 02Investigate the function of NQO2 in red blood cell damage from primaquine
AIM 03Examine the combined effects of NQO1 and NQO2 on oxidative stress in G6PD deficient mice
Skills the Lab Values
mouse modelsgene editingflow cytometrycell culturebiochemical assaysRNA extractionWestern blottingmetabolomicsin vivo imaging
Output against the department
Publications91bottom 30% of dept.721st of 1,033
this lab
most publishedleast published
Citations1.9kbottom 13% of dept.899th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.