Yale University · NeuroscienceStrittmatter Neurobiology Lab
Stephen M Strittmatter · New Haven, Connecticut
Research Focus
Dr. Stephen Strittmatter's lab at Yale University focuses on understanding the mechanisms of synapse loss in Alzheimer's disease. The research investigates how a specific receptor in the brain, called mGluR5, contributes to the disease's progression and memory impairment. By using advanced imaging techniques and genetic models, the lab aims to discover new therapeutic approaches to prevent synapse loss and improve brain function in Alzheimer's patients.
Alzheimer's Diseasesynaptic lossmGluR5neurodegenerationgene profilingcryogenic electron microscopyneural signalingdrug developmentiPSC-derived neurons
Research Aims
5AIM 01Investigate the role of mGluR5 in synaptic loss associated with Alzheimer's disease.
AIM 02Profile gene expression in brain cells using single-cell transcriptomics.
AIM 03Utilize cryo-electron microscopy to study the structural changes in mGluR5 in Alzheimer's.
AIM 04Test therapeutic compounds that target mGluR5 in relevant animal models.
AIM 05Understand the interaction between mGluR5 and glial cells in the context of neurodegeneration.
Skills the Lab Values
cell culturemouse modelslongitudinal PET imagingsingle-cell transcriptomicscryogenic electron microscopygenetic engineering (CRISPR)fluorescence resonance energy transfer (FRET)biochemical assaysprotein analysisbioinformatics
Output against the department
Publications372top 17% of dept.114th of 671
this lab
most publishedleast published
Citations41ktop 8% of dept.55th of 671
this lab
most citedleast cited
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