Tulane University of Louisiana · BiochemistryPediatric TB Diagnostics Lab
Christopher J Lyon · New Orleans, Louisiana
Research Focus
Dr. Christopher J Lyon's lab focuses on improving the diagnosis and management of tuberculosis (TB) in children, particularly those under five years old. The lab is developing a novel blood-based assay that detects proteins from the TB pathogen and the host's immune response using advanced immunoassay technology. By leveraging accessible diagnostic methods, the research aims to enhance the sensitivity and accuracy of TB detection in pediatric patients, especially in resource-limited settings.
tuberculosispediatric healthextracellular vesiclesdiagnostic assaysbiomarkersimmune responsepathogen detectionserum analysisportable diagnostics
Research Aims
4AIM 01Optimize the EV biomarker signature using Mtb- and host-derived proteins from serum samples.
AIM 02Conduct analytical validation of the NEI assay to establish its performance characteristics.
AIM 03Develop a prediction model for the NEI array's effectiveness in diagnosing TB and evaluating treatment responses.
AIM 04Validate the NEI arrays for diagnosing latent TB infection and active TB in older children.
Skills the Lab Values
immunoassayserum biomarker analysisextracellular vesicle isolationbiological sample processingdata validationclinical cohort studiesmass spectrometry techniquesanalytical testingbioinformaticslongitudinal study design
Output against the department
Publications173top 50% of dept.198th of 402
this lab
most publishedleast published
Citations9.9ktop 49% of dept.198th of 402
this lab
most citedleast cited
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