University of Minnesota-Twin Cities · BiologySchwertfeger Lab
Kathryn L Schwertfeger · Minneapolis, Minnesota
Research Focus
Dr. Kathryn Schwertfeger's research lab at the University of Minnesota focuses on breast cancer, specifically how immune cells, particularly macrophages, interact with tumors. The lab investigates signaling pathways that affect macrophage behavior, aiming to enhance the body’s anti-tumor immune response. By understanding how these pathways work, the research hopes to develop new treatments that can improve cancer outcomes for patients.
breast cancertumor-associated macrophagesSTAT5immune responsecancer therapy
Research Aims
3AIM 01Investigate STAT5 signaling in tumor-associated macrophages during breast cancer progression.
AIM 02Determine the effects of GM-CSF on macrophage activation and its relation to STAT5.
AIM 03Develop new methods to restore STAT5 function in macrophages and assess its impact on tumor growth.
Skills the Lab Values
mouse modelsgenetic knockout techniquescell cultureimmunohistochemistrymultiplex imaging
Output against the department
Publications252top 24% of dept.245th of 1,033
this lab
most publishedleast published
Citations4.1kbottom 31% of dept.713th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.