New York University · BiologyGresham Quiescence Lab
David Gresham · New York, New York
Research Focus
David Gresham's lab at NYU studies how cells respond to nutrient deprivation and adapt through rapid evolution. They focus on understanding cell quiescence, a state where cells remain inactive but can react to challenges, and how certain genetic changes can lead to rapid adaptations in microbes. This research has implications for improving antifungal treatments and understanding diseases influenced by genetic variation.
cell quiescencenutritional stresscopy number variationfungal pathogensadaptive evolution
Research Aims
5AIM 01Investigate how protein expression changes in quiescent cells during nutrient deprivation.
AIM 02Study the role of signaling pathways in remodeling cell biology under stress.
AIM 03Quantify genetic factors that influence drug tolerance in quiescent fungal cells.
AIM 04Analyze the dynamics of copy number variation in microbial populations under evolving conditions.
AIM 05Model the fitness costs and benefits associated with copy number variation.
Skills the Lab Values
mass spectrometrylive cell imagingsingle-cell RNA sequencingmetabolic labelinggenetic manipulation
Output against the department
Publications149top 46% of dept.471st of 1,033
this lab
most publishedleast published
Citations7.2ktop 50% of dept.521st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.