Wayne State University · BiologyKim Oncology Lab
Hyeong-Reh Choi Kim · Detroit, Michigan
Research Focus
Dr. Hyeong-Reh Choi Kim's lab focuses on developing innovative treatments for castrate-resistant prostate cancer. The research aims to create and test new therapeutic agents that target and degrade androgen receptors, helping to overcome resistance to current therapies. Using advanced animal models and molecular techniques, the lab seeks to enhance our understanding of prostate cancer progression and identify effective alternatives to existing treatments.
prostate cancerandrogen receptorAR degradationcastrate-resistant prostate cancerAUTOTACantitumor therapycell signalingtumor microenvironmentsingle cell RNA-seq
Research Aims
5AIM 01Develop novel AR-targeting therapeutic agents using AUTOTAC technology.
AIM 02Characterize the molecular actions and therapeutic efficacy of AR-targeted AUTOTACs in prostate cancer cell models.
AIM 03Evaluate the efficacy of AUTOTACs in relevant animal models of prostate cancer.
AIM 04Examine the effects of drug treatments on tumor heterogeneity and cellular plasticity.
AIM 05Identify additional therapeutic targets in castrate-resistant prostate cancer through transcriptome analysis.
Skills the Lab Values
cell cultureanimal modelsPCRWestern blotRNA sequencingin vivo experimentationdrug treatment efficacy testingbiochemical assaysmolecular biology techniques
Output against the department
Publications80bottom 23% of dept.787th of 1,033
this lab
most publishedleast published
Citations6.6kbottom 47% of dept.550th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.